Masahide Sakaue. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12879-019-4350-3. RCoPo; London: 1886. No family history of note was elicited. Clostridium perfringenssepsis has been ascribed a dismal prognosis when associated with massive intravascular haemolysis. In addition, C. perfringens induces the fatal disease gas gangrene, which causes myonecrosis… If food that contains spores is not eaten soon after it is cooked, the spores develop into active clostridia bacteria, which then multiply in the food. In this context, combined use of transthoracic echocardiography and pulmonary artery catheter monitoring is able to yield an individualized … 2015;10(11):e0138183. Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 2020 Feb 28;20:e00736. Other data were as follows: white blood cell count, 20,900/mm3 with 85.6% neutrophils; C-reactive protein, 4.70 mg/dL; procalcitonin, 28.82 ng/mL; platelet count, 545,000/μL; blood urea nitrogen, 27 mg/dL; creatinine, 2.42 mg/dL; serum aspartate aminotransferase, 874 IU/ L; serum alanine aminotransferase, 299 IU/L; and lactate dehydrogenase, 7605 IU/L; Na, 124 mEq/L; Cl, 92 mEq/L; K, 5.8 mEq/L. Colen CB, Rayes M, Rengachary S, Guthikonda M. Neurosurgery. However, when abnormally high levels of this bacteria is found in the intestine, it can lead to Clostridial enterotoxicosis. Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and... Background. Necrotizing enteritis (enteritis necroticans, NEC) is a life-threatening infection caused by Clostridium perfringens type C and type A and characterized by ischemic necrosis of the jejunum and gas in the tissue plane. One side of the plate contains anti-alpha-toxin, while the other side does not. 1. Other articles where Clostridium perfringens is discussed: clostridial infection: Enterotoxins produced by C. perfringens cause several gastrointestinal diseases in sheep, including lamb dysentery, struck, and pulpy kidney. SY identified type of Clostridium perfringens using Multiplex polymerase chain reaction. Arterial blood gas analysis revealed metabolic acidosis and compensatory respiratory alkalosis (pH, 7.486; partial pressure of arterial carbon dioxide, 16.1 mmHg; partial pressure of arterial oxygen, 66.1 mmHg; lactate, 86.4 mg/dL; base excess, − 9.2 mmol/L). Int J Surg Case Rep. 2017;41:180–3. Liver Transpl. A computer tomography of the abdomen revealed a 7×5,6cm sized entrapped air in liver segment VII. Heart sounds were normal, the lungs were clear to auscultation, and results of neurological and skin examinations were unremarkable. Despite these ED workups, however, his condition rapidly deteriorated and cardiopulmonary arrest occurred suddenly, 150 min after arrival in the ED. -, Rives C., Chaudhari D., Swenson J., Reddy C., Young M. Clostridium perfringens liver abscess complicated by bacteremia. A 7 × 6 cm sized lesion surrounded by air in the right lobe of the liver became evident (marked by the yellow star). Type A fulminant Clostridium perfringens sepsis indicated RBC/Hb discrepancy; a case report Abstract. Later the patient developed a multiorgan failure. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Identification and characterization of a new enterotoxin produced by Clostridium perfringens isolated from food poisoning outbreaks. | BMC Infect Dis 19, 719 (2019). Laboratory examination revealed a discrepancy between the red blood cell count (RBC) of 1.91 × 106/mm3 and the hemoglobin (Hb) level of 10.3 g/dL. Clostridium perfringens. C. perfringens septicemia is rare, but is a known cause of hemolysis by damaging red blood cell, and often proves rapidly fatal in emergency department (ED) situations. 2007 Dec;61(6):E1339; discussion E1339. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Clostridium perfringens C. perfringens is a gram-positive spore-forming anaerobic (meaning it can grow without oxygen) bacteria that is normally found in the intestines of humans and animals. Written informed consent to participate was obtained from the patient‘s wife and child. 1) UCTN:E457. Clostridium perfringens (C. perfringens) is one of the most common causes of food poisoning in the United States.CDC estimates C. perfringens causes nearly 1 million cases of foodborne illness each year in the United States.. Find out more about this germ and steps you can take to prevent illness. Z Geburtshilfe Neonatol. Clostridium perfringens is currently known to … Endoscopy. Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and fasciitis. The illness usually begins suddenly and lasts for less than 24 hours. Cochrane J, Bland L, Noble M. Intravascular hemolysis and septicemia due to Clostridium perfringens emphysematous cholecystitis and hepatic abscesses. Chronic liver diseases, immunosuppression, and presence of malignancies were risk factors for Clostridium perfringens sepsis. Sakaue M, Ota K, Nakamura E, Nitta M, Oka M, Oishi Y, Sano Y, Yonogi S, Takasu A. BMC Infect Dis. In the present case, the patient deteriorated rapidly and died despite administration of a broad-spectrum antibiotic soon after arrival. The key treatments for this rapidly lethal infection include immediate administration of antibiotics and surgical intervention. Anaerobe. Gas gangrene is caused by a rod shaped, gram positive, spore forming bacterium called Clostridium perfringens. Abdominal examination revealed mild tenderness in the periumbilical region. During ED treatment, the state of the patient rapidly deteriorated and he entered cardiopulmonary arrest. Clostridium perfringens; Gas gangrene; Klebsiella oxytoca; Liver abscess; Sepsis. He had eaten no perishable foods, and no family members had shown any symptoms. USA.gov. Article NIH The gallbladder was found inflamed. The neck was supple. Clipboard, Search History, and several other advanced features are temporarily unavailable. Clostridium perfringens is commonly found in the surrounding environment and is isolated from the intestinal tract of humans. All types of C. perfringens produce α toxin , which has been reported to hydrolyze phospholipids in red blood cell membranes, leading to massive hemolysis and severe tissue hypoxia due to the failure of oxygen transport functions [2, 5]. The anaerobic, necrotic environment of wounded tissue allows spores to germinate and elaborate powerful exotoxins which promote further tissue necrosis. An area of turbidity will form around the si… C. perfringens septicemia is a rare, but rapidly fatal disease with a reported mortality rate of at least 60% . 2012;4(8):252–255. Such manifestations of C. perfringens infection are rare but well-documented in the medical literature. 5 ] bacteria that can infect the bowel in people and animals: https //doi.org/10.1186/s12879-019-4350-3! 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